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Dogs’ bodies can sometimes produce too many white blood cells, and it’s fascinating how this ties into their heart health. Unpacking these connections might just change how we approach their care. Curious to see what signs to watch for?
https://www.petmd.com/dog/conditions/cardiovascular/c_dg_overproduction_white_blood_cells
#DogHealth #CanineCare #HeartConditions
https://www.petmd.com/dog/conditions/cardiovascular/c_dg_overproduction_white_blood_cells
#DogHealth #CanineCare #HeartConditions
Dogs’ bodies can sometimes produce too many white blood cells, and it’s fascinating how this ties into their heart health. Unpacking these connections might just change how we approach their care. Curious to see what signs to watch for?
https://www.petmd.com/dog/conditions/cardiovascular/c_dg_overproduction_white_blood_cells
#DogHealth #CanineCare #HeartConditions
%20in%20the%20bone%20marrow.%22,%22articleBody%22:%22Hypereosinophilic%20Syndrome%20in%20Dogs%20Hypereosinophilic%20syndrome%20is%20a%20disorder%20of%20unknown%20cause,%20characterized%20by%20persistent%20eosinophilia%20--%20sustained%20overproduction%20of%20eosinophils%20(white%20blood%20cells%20of%20the%20immune%20system)%20in%20the%20bone%20marrow.%20However,%20its%20suspected%20cause%20is%20a%20link%20to%20a%20severe%20reaction%20to%20an%20unidentified%20antigen,%20or%20impairment%20of%20the%20immune%20response%20and%20control%20of%20eosinophil%20production.%20This%20is%20a%20multi-system%20syndrome,%20with%20invasion%20of%20the%20tissues%20by%20eosinophils%20and%20subsequent%20organ%20damage%20and%20dysfunction.%20It%20frequently%20has%20a%20fatal%20outcome.%20Organ%20damage%20can%20result%20from%20the%20effects%20of%20eosinophil%20granule%20products%20and%20eosinophil-derived%20cytokines,%20a%20category%20of%20regulatory%20proteins%20that%20are%20released%20by%20cells%20in%20the%20immune%20system%20into%20the%20tissues.%20Common%20sites%20of%20infiltration%20include%20the%20gastrointestinal%20tract%20(especially%20the%20intestine%20and%20liver),%20spleen,%20bone%20marrow,%20lungs,%20and%20lymph%20nodes%20(especially%20those%20in%20the%20abdominal%20area).%20Less%20common%20sites%20of%20infiltration%20include%20the%20skin,%20kidney,%20heart,%20thyroid,%20adrenal%20glands%20and%20pancreas.%20This%20condition%20is%20rare%20in%20dogs,%20but%20Rottweilers%20may%20be%20predisposed.%20Symptoms%20Lethargy%20Fever%20Loss%20of%20appetite%20(anorexia)%20Intermittent%20vomiting%20and%20diarrhea%20Weight%20loss%20Emaciation%20Enlargement%20of%20the%20liver%20and%20spleen%20Thickened%20(diffuse%20or%20segmental)%20intestine%20that%20is%20non-painful%20Abdominal%20masses%20Itching%20and%20seizures%20(less%20frequently)%20Mesenteric%20and%20possibly%20peripheral%20lymphadenopathy%20(swollen%20lymph%20nodes%20in%20the%20abdominal%20region%20or%20other%20areas%20of%20the%20body)%20Mass%20lesions%20caused%20by%20eosinophilic%20granulomatous%20(inflamed%20masses%20of%20tissue)%20involving%20the%20lymph%20nodes%20and%5C/or%20organsCauses%20The%20cause%20of%20hypereosinophilic%20syndrome%20is%20unknown.%20However,%20it%20is%20believed%20to%20be%20cause%20by%20a%20severe%20reaction%20to%20an%20underlying,%20as%20yet%20unidentifiable%20antigenic%20stimulus%20that%20may%20be%20composed%20of%20two%20different%20strains%20of%20a%20virus.%20Diagnosis%20The%20veterinary%20examination%20will%20consist%20of%20standard%20laboratory%20work,%20including%20a%20complete%20blood%20profile,%20chemical%20blood%20profile,%20a%20complete%20blood%20count,%20and%20a%20urinalysis.%20You%20will%20need%20to%20give%20a%20thorough%20history%20of%20your%20dog's%20health%20and%20onset%20of%20symptoms.%20Additional%20diagnostics%20will%20include%20a%20bone%20marrow%20aspiration%20and%5C/or%20core%20biopsy%20of%20the%20cells,%20and%20a%20biopsy%20of%20the%20affected%20organ%20or%20mass.%20It%20is%20typical%20for%20the%20blood%20test%20results%20to%20show%20increased%20amounts%20of%20multiple%20types%20of%20white%20blood%20cells,%20most%20notably%20leukocytosis%20(leukocyte),%20basophilia%20(basophil),%20and%20eosinophilia%20(eosinophil).%20The%20results%20of%20the%20blood%20tests%20may%20also%20show%20anemic%20conditions,%20and%20the%20biochemical%20profile%20may%20show%20abnormalities%20in%20the%20case%20of%20organ%20dysfunction.%20Diagnostic%20imaging%20can%20be%20helpful%20in%20determining%20the%20extent%20of%20organ%20damage%20as%20well.%20Radiographic%20contrast,%20which%20uses%20an%20injection%20of%20a%20radiocontrasting%20agent%20into%20the%20area%20to%20be%20viewed,%20may%20be%20used%20to%20improve%20visibility%20of%20the%20internal%20organs.%20These%20X-rays%20may%20show%20thickened%20intestines%20and%20abnormalities%20in%20the%20lining%20of%20the%20intestines.%20Other%20findings%20may%20be%20reactive%20hyperplasia%20(abnormal%20enlargement)%20of%20the%20lymph%20nodes%20due%20to%20eosinophil%20infiltration,%20and%20fibrosis%20(excess%20fibrous%20connective%20tissue)%20and%20thrombosis%20(coagulation%20in%20the%20arteries)%20surrounding%20the%20heart.%20Treatment%20Long-term%20maintenance%20therapy%20will%20be%20employed%20to%20control%20or%20reduce%20the%20eosinophilia%20and%20organ%20damage.%20High%20serum%20immunoglobulin%20concentrations%20(the%20fraction%20of%20the%20blood%20serum%20that%20contains%20antibodies)%20can%20signify%20a%20good%20response%20to%20treatment%20with%20prednisone,%20a%20corticosteroid%20given%20to%20reduce%20inflammation,%20and%20therefore%20a%20better%20prognosis.%20Prednisone%20can%20be%20effective%20at%20suppressing%20eosinophil%20production.%20In%20some%20cases,%20chemotherapy%20may%20be%20appropriate%20for%20inhibiting%20DNA%20synthesis,%20in%20effect,%20reducing%20the%20reproduction%20of%20cells.%20Massive%20tissue%20infiltration%20can%20impede%20treatment%20and%20usually%20leads%20to%20a%20poor%20prognosis.%20Living%20and%20Management%20Your%20veterinarian%20will%20schedule%20follow-up%20examinations%20for%20your%20dog%20to%20monitor%20eosinophil%20count%20(not%20always%20indicative%20of%20tissue%20infiltrates)%20and%20myelosuppression%20(by%20which%20bone%20marrow%20activity%20is%20decreased)%20if%20chemotherapeutic%20drugs%20are%20being%20used.%20Clinical%20signs%20will%20also%20be%20monitored%20along%20with%20any%20physical%20abnormalities%20(e.g.%20loss%20of%20appetite,%20lethargy,%20vomiting,%20and%20diarrhea).%22%7D){kind=logo}
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%20in%20Dogs%22,%22inLanguage%22:%22en-US%22,%22isFamilyFriendly%22:%22True%22,%22articleSection%22:%22Cardiovascular%22,%22thumbnailUrl%22:%22%22,%22image%22:%7B%22@type%22:%22ImageObject%22,%22url%22:%22%22%7D,%22author%22:%7B%22@type%22:%22Person%22,%22name%22:%22PetMD%20Editorial%22,%22url%22:%22https:%5C/%5C/www.petmd.com%5C/author%5C/tierischgut%22%7D,%22keywords%22:%22Dog,%20Condition,%20Cardiac%20health%22,%22publisher%22:%7B%22@type%22:%22Organization%22,%22name%22:%22PetMD%22,%22logo%22:%7B%22@type%22:%22ImageObject%22,%22url%22:%22https:%5C/%5C/www.petmd.com%5C/images%5C/petmd_logo.png%22%7D,%22url%22:%22https:%5C/%5C/www.petmd.com%22%7D,%22mainEntityOfPage%22:%7B%22@type%22:%22WebPage%22,%22@id%22:%22https:%5C/%5C/www.petmd.com%5C/dog%5C/conditions%5C/cardiovascular%5C/c_dg_atrioventricular_block_first_degree%22%7D,%22datePublished%22:%222009-12-17T04:42:11-05:00%22,%22dateModified%22:%222022-08-16T09:29:15-04:00%22,%22description%22:%22A%20normal%20heart%20contraction%20is%20caused%20by%20an%20electrical%20impulse%20originating%20from%20the%20sinoatrial%20node,%20stimulating%20the%20atria,%20traveling%20to%20the%20atrioventricular%20node%20and%20finally%20to%20the%20ventricles.%20First-degree%20atrioventricular%20block%20is%20a%20condition%20in%20which%20the%20electrical%20conduction%20from%20the%20atria%20to%20the%20ventricles%20is%20delayed,%20or%20prolonged.%22,%22articleBody%22:%22Atrioventricular%20Block,%20First%20Degree%20in%20Dogs%20A%20normal%20heart%20contraction%20is%20caused%20by%20an%20electrical%20impulse%20originating%20from%20the%20sinoatrial%20node,%20stimulating%20the%20atria,%20traveling%20to%20the%20atrioventricular%20node%20and%20finally%20to%20the%20ventricles.%20First-degree%20atrioventricular%20block%20is%20a%20condition%20in%20which%20the%20electrical%20conduction%20from%20the%20atria%20to%20the%20ventricles%20is%20delayed,%20or%20prolonged.%20On%20an%20electrocardiogram%20(EKG)%20this%20shows%20as%20a%20prolonged%20PR%20interval%20--%20the%20time%20between%20the%20main%20electrical%20impulse,%20called%20the%20P%20wave,%20and%20the%20QRS%20complex,%20which%20is%20recognized%20as%20the%20heart%20beat.%20First-degree%20AV%20block%20may%20be%20found%20in%20young,%20healthy%20dogs%20due%20to%20a%20high%20vagal%20tone%20(impulses%20from%20the%20vagus%20nerve%20that%20produce%20an%20inhibition%20in%20the%20heart%20beat),%20and%20it%20is%20also%20often%20noted%20in%20elderly%20Cocker%20Spaniels%20and%20Dachshunds%20with%20degenerative%20conduction%20system%20disease.%20Symptoms%20and%20Types%20Most%20dogs%20with%20this%20condition%20will%20not%20show%20signs%20of%20the%20condition.%20However,%20if%20induced%20by%20digoxin%20(heart%20medication)%20overdose,%20there%20may%20be%20a%20loss%20of%20appetite,%20vomiting,%20and%20diarrhea.%20Causes%20Although%20it%20may%20occur%20in%20otherwise%20healthy%20dogs,%20Dachshunds%20and%20Cocker%20Spaniels%20are%20known%20to%20be%20more%20prone%20to%20first-degree%20AV%20block.%20Additionally,%20prescription%20medication%20such%20as%20digoxin,%20bethanechol,%20physostigmine,%20and%20pilocarpine,%20may%20predispose%20animals%20to%20first-degree%20AV%20block.%20Some%20other%20common%20causes%20for%20the%20condition%20include:%20Calcium%20deficiencyDegenerative%20disease%20of%20the%20electrical%20conduction%20systemHypertrophic%20cardiomyopathyInflammation%20of%20the%20heartInfiltrative%20diseases%20(tumors,%20amyloidosis)Atropine%20(used%20to%20control%20spasms)%20administered%20intravenously%20may%20also%20briefly%20prolong%20the%20PR%20intervalDiagnosis%20In%20addition%20to%20the%20full%20physical%20exam,%20your%20veterinarian%20will%20take%20a%20complete%20background%20history%20of%20your%20dog's%20health,%20when%20the%20symptoms%20began%20and%20any%20other%20symptoms%20that%20may%20point%20your%20doctor%20to%20the%20underlying%20cause.%20Standard%20tests%20include%20a%20chemical%20blood%20profile%20and%20a%20complete%20blood%20count%20to%20check%20for%20imbalances%20or%20infections.%20An%20echocardiogram%20(EKG)%20will%20be%20conducted%20to%20rule%20out%20certain%20types%20of%20heart%20diseases,%20and%20X-ray%20or%20ultrasound%20imaging%20can%20be%20used%20for%20internal%20imaging%20of%20the%20heart,%20confirming%20the%20presence%20of%20masses,%20or%20ruling%20them%20out.%20Gastrointestinal%20disorders,%20high%20pressure%20in%20the%20eye%20and%20upper%20airway%20disease%20are%20some%20of%20the%20diseases%20that%20can%20lead%20this%20disorder,%20all%20of%20which%20are%20unrelated%20(directly)%20to%20the%20heart.%20An%20EKG%20recording%20can%20be%20used%20to%20examine%20the%20electrical%20currents%20in%20the%20heart%20muscles,%20and%20may%20reveal%20the%20exact%20abnormalities%20that%20are%20taking%20place%20in%20the%20cardiac%20electrical%20conduction%20(which%20underlies%20the%20heart%5Cu2019s%20ability%20to%20contract%5C/beat).%20Treatment%20Depending%20on%20the%20underlying%20disease%20causing%20the%20atrioventricular%20block,%20treatment%20will%20vary.%20Living%20and%20Management%20Your%20veterinarian%20will%20prescribe%20diet%20guidelines%20as%20necessary%20to%20treat%20the%20underlying%20cause%20of%20the%20disease.%20You%20will%20need%20to%20follow-up%20with%20your%20veterinarian%20for%20regular%20appointments%20so%20that%20any%20changes%20can%20be%20addressed%20immediately.%20EKGs%20will%20be%20taken%20at%20each%20visit%20to%20follow%20the%20progress%20of%20the%20heart's%20ability%20to%20conduct%20properly.%20%22%7D){kind=logo}
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