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Hepatic amyloidosis in dogs isn't something you hear about every day, but learning how this condition affects the liver opens up a new understanding of canine health challenges. A reminder just how complex—and delicate—our pets’ bodies can be. Worth exploring deeper.
https://www.petmd.com/dog/conditions/endocrine/c_dg_hepatic_amyloidosis
#doghealth #caninediseases #veterinarycare
https://www.petmd.com/dog/conditions/endocrine/c_dg_hepatic_amyloidosis
#doghealth #caninediseases #veterinarycare
Hepatic amyloidosis in dogs isn't something you hear about every day, but learning how this condition affects the liver opens up a new understanding of canine health challenges. A reminder just how complex—and delicate—our pets’ bodies can be. Worth exploring deeper.
https://www.petmd.com/dog/conditions/endocrine/c_dg_hepatic_amyloidosis
#doghealth #caninediseases #veterinarycare
%20in%20Dogs%22,%22inLanguage%22:%22en-US%22,%22isFamilyFriendly%22:%22True%22,%22articleSection%22:%22Endocrine%22,%22thumbnailUrl%22:%22%22,%22image%22:%7B%22@type%22:%22ImageObject%22,%22url%22:%22%22%7D,%22author%22:%7B%22@type%22:%22Person%22,%22name%22:%22PetMD%20Editorial%22,%22url%22:%22https:%5C/%5C/www.petmd.com%5C/author%5C/vheuer%22%7D,%22keywords%22:%22Dog,%20Condition,%20Liver%20health%22,%22publisher%22:%7B%22@type%22:%22Organization%22,%22name%22:%22PetMD%22,%22logo%22:%7B%22@type%22:%22ImageObject%22,%22url%22:%22https:%5C/%5C/www.petmd.com%5C/images%5C/petmd_logo.png%22%7D,%22url%22:%22https:%5C/%5C/www.petmd.com%22%7D,%22mainEntityOfPage%22:%7B%22@type%22:%22WebPage%22,%22@id%22:%22https:%5C/%5C/www.petmd.com%5C/dog%5C/conditions%5C/endocrine%5C/c_dg_hepatic_amyloidosis%22%7D,%22datePublished%22:%222009-06-29T14:02:56-04:00%22,%22dateModified%22:%222022-08-16T09:30:37-04:00%22,%22description%22:%22Hepatic%20amyloidosis%20is%20the%20deposition%20of%20amyloid%20in%20the%20liver.%20The%20accumulation%20of%20amyloid%20often%20occurs%20secondary%20to%20an%20underlying%20inflammatory%20or%20lympho-proliferative%20disorder.%20For%20example,%20when%20lymphocytes,%20a%20type%20of%20white%20blood%20cell,%20are%20produced%20in%20excessive%20quantities,%20amyloidosis%20can%20be%20a%20reaction%20to%20this%20condition.%22,%22articleBody%22:%22Hepatic%20Amyloidosis%20in%20Dogs%20Amyloidosis%20refers%20to%20a%20group%20of%20disorders%20that%20share%20a%20common%20feature:%20the%20pathologic%20abnormal%20deposition%20of%20a%20fibrous%20protein%20called%20amyloid%20into%20various%20tissues%20of%20the%20body.%20Hepatic%20amyloidosis%20is%20the%20deposition%20of%20amyloid%20in%20the%20liver.%20The%20accumulation%20of%20amyloid%20often%20occurs%20secondary%20to%20an%20underlying%20inflammatory%20or%20lympho-proliferative%20disorder.%20For%20example,%20when%20lymphocytes,%20a%20type%20of%20white%20blood%20cell,%20are%20produced%20in%20excessive%20quantities,%20amyloidosis%20can%20be%20a%20reaction%20to%20this%20condition.%20Or,%20it%20can%20occur%20as%20a%20familial%20disorder.%20Most%20affected%20dogs%20are%20thought%20to%20have%20reactive%20or%20secondary%20amyloidosis%20affiliated%20with%20an%20underlying%20primary%20inflammatory%20disorder.%20Familial%20amyloidosis%20has%20been%20described%20in%20certain%20dog%20breeds.%20The%20most%20commonly%20affected%20breeds%20are%20beagles,%20shar%20peis,%20and%20foxhounds.%20Multiple%20organs%20are%20commonly%20involved.%20Clinical%20signs%20are%20usually%20associated%20with%20renal%20(kidney)%20involvement.%20Or%20it%20may%20be%20associated%20with%20high%20liver%20enzymes,%20severe%20enlargement%20of%20the%20liver,%20coagulation%20disorders,%20liver%20rupture%20leading%20to%20hemoabdomen%20(blood%20in%20the%20abdomen),%20and%5C/or%20liver%20failure.%20Liver%20amyloid%20accumulation%20is%20often%20insidious.%20Certain%20Chinese%20shar-pei%20dogs%20with%20cyclic%20fevers%20(known%20as%20shar-pei%20fever%20syndrome),%20Akitas%20with%20cyclic%20fever%20and%20multiple%20joint%20inflammations,%20and%20collies%20with%20%5Cu201cgray%20collie%20syndrome%5Cu201d%20are%20predisposed%20to%20developing%20amyloidosis.%20They%20usually%20develop%20renal%20signs%20first%20although%20some%20develop%20symptoms%20of%20liver%20failure%20first.%20Symptoms%20and%20Types%20Episodic%20fever%20and%20swollen%20hocks%20(Shar-peis)%20Episodic%20joint%20inflammation,%20pain,%20and%20signs%20of%20meningitis%20(Akitas)%20Sudden%20lack%20of%20energy%20Anorexia%20(loss%20of%20appetite)%20Polyuria%20and%20polydipsia%20(excess%20thirst%20and%20excess%20urination)%20Vomiting%20Pallor%20Abdominal%20fluid%20%5Cu2013%20blood%20or%20fluid%20Yellowish%20skin%20and%5C/or%20whites%20of%20eyes%20Enlarged%20abdomen%20Swelling%20Joint%20pain%20Diffuse%20pain:%20head%20pain,%20and%20abdominal%20discomfortCauses%20Familial%20immune%20disorders%5C/genetics%20Chronic%20infection%20Cyclic%20neutropenia%20(gray%20collie%20syndrome)%20Bacterial%20endocarditis%20(inflammation%20of%20the%20inner%20layer%20of%20the%20heart)%20Chronic%20inflammation%20TumorDiagnosis%20You%20will%20need%20to%20give%20a%20thorough%20history%20of%20your%20dog's%20health%20and%20onset%20of%20symptoms.%20The%20history%20you%20provide%20may%20give%20your%20veterinarian%20clues%20as%20to%20which%20organs%20are%20being%20primarily%20affected.%20Your%20veterinarian%20will%20perform%20a%20complete%20physical%20exam,%20with%20a%20blood%20chemical%20profile,%20a%20complete%20blood%20count,%20an%20electrolyte%20panel%20and%20a%20urinalysis.%20These%20basic%20fluid%20tests%20are%20essential%20diagnostic%20tools%20for%20ruling%20out%20other%20causes%20of%20disease.%20The%20complete%20blood%20count%20will%20show%20any%20anemia%20which%20might%20be%20present%20due%20to%20internal%20bleeding%20or%20long-term%20disease,%20or%20it%20may%20indicate%20infection.%20The%20blood%20chemical%20profile%20may%20show%20kidney%20and%20liver%20abnormalities,%20and%20the%20urinalysis%20may%20show%20renal%20disease.%20A%20clotting%20profile%20should%20also%20be%20performed%20on%20a%20blood%20sample%20to%20check%20the%20liver%5Cu2019s%20functionality.%20X-ray%20and%20ultrasound%20imaging%20may%20also%20reveal%20abnormalities%20in%20organs%20where%20amyloid%20might%20be%20collecting.%20If%20necessary,%20a%20minor%20surgery%20can%20also%20be%20performed%20to%20collect%20a%20sample%20for%20biopsy%20of%20the%20liver%20and%5C/or%20other%20organs.%20Dogs%20with%20swelling%20in%20the%20joints%20should%20have%20joint%20taps%20taken.%20Cytology%20%5Cu2013%20a%20microscopic%20examination%20of%20the%20cells%20present%20in%20the%20fluid%20-%20of%20these%20samples%20can%20be%20performed%20to%20confirm%20or%20rule%20out%20the%20presence%20of%20malignancies%20in%20the%20cells.%20The%20composition%20of%20any%20fluid%20that%20has%20built%20up%20in%20the%20abdomen%20can%20also%20be%20analyzed%20at%20the%20laboratory.%20Treatment%20There%20is%20no%20cure%20for%20amyloidosis,%20but%20supportive%20care%20is%20very%20helpful.%20Blood%20transfusions%20should%20be%20administered%20if%20your%20dog%20has%20recently%20lost%20a%20lot%20of%20blood,%20and%20fluid%20therapy%20and%20possible%20diet%20changes%20will%20need%20to%20be%20undertaken.%20Each%20patient%20should%20have%20its%20diet%20tailored%20to%20suit%20the%20organ%20function%20that%20is%20being%20affected%20most.%20Surgery%20intervention%20may%20be%20necessary%20if%20there%20is%20a%20fractured%20liver%20lobe,.%20Living%20and%20Management%20This%20syndrome%20is%20difficult%20to%20treat%20and%20has%20a%20guarded%20to%20poor%20prognosis.%20Most%20animals%20will%20have%20episodes%20of%20fever%20and%20cholestasis,%20where%20bile%20cannot%20flow%20from%20the%20liver%20to%20the%20duodenum%20(small%20intestine).%20Some%20dogs%20will%20benefit%20from%20medication,%20with%20resolved%20clinical%20signs%20and%20diminished%20hepatic%20amyloid.%20Shar-peis%20may%20survive%20more%20than%20two%20years.%20However,%20Akitas%20with%20cyclic%20clinical%20signs%20have%20a%20grave%20prognosis.%20Your%20veterinarian%20will%20schedule%20follow-up%20appointments%20with%20you%20for%20your%20dog%20as%20is%20necessary%20to%20monitor%20its%20organ%20function.%20Your%20veterinarian%20will%20schedule%20follow-up%20appointments%20with%20you%20for%20your%20dog%20as%20is%20necessary%20to%20monitor%20its%20organ%20function.%22%7D){kind=spacer}
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